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KMID : 0357920130470020100
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Korean Journal of Pathology
2013 Volume.47 No. 2 p.100 ~ p.106
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Guideline Recommendations for EGFR Mutation Testing in Lung Cancer: Proposal of the Korean Cardiopulmonary Pathology Study Group
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Shim Hyo-Sup
Chung Jin-Haeng
Kim Lucia
Chang Sun-Hee
Kim Wan-Seop
Lee Geon-Kook
Jung Soon-Hee
Jang Se-Jin
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Abstract
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Mutations of the epidermal growth factor receptor (EGFR) are the strongest predictive factor for response to EGFR tyrosine kinase inhibitors (TKIs), such as gefitinib and erlotinib. EGFR TKIs are approved in Korea as a first-line treatment for lung cancer patients with mutated EGFR. Rapid and accurate EGFR mutation testing is essential for patient selection and establishing targeted therapies with EGFR TKIs. Thus, a standard set of guideline recommendations for EGFR mutation testing suitable for the Korean medical community is necessary. In this article, we propose a set of guideline recommendations for EGFR mutation testing that was discussed and approved by the Cardiopulmonary Pathology Study Group of the Korean Society of Pathologists.
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KEYWORD
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Mutation, Receptor, epidermal growth factor, Guideline
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